The adaptive immune response can detect and eliminate diseased cells, including cancer cells. However, during tumor evolution under immune-selective pressure, cancer cells find ways to disrupt anti-tumor immunity and evade immune-mediated killing. A deeper understanding of the mechanisms that hinder effective anti-tumor immunity and enable immune evasion is crucial for advancing the development of more effective or novel cancer immunotherapies.

Our research seeks to uncover these underlying mechanisms of immune escape, with the goal of translating our findings into innovative immunotherapeutic strategies for cancer patients. We are particularly focused on hematological malignancies and the role of immune escape in evading anti-tumor T cell responses, which are critical mediators of tumor control.